Injection site reaction to adalimumab: Positive skin test and successful rapid desensitisation.

ibuprofen was positive in a residual lesion, while patch test with the same drug was negative in upper back. We were curious to know if our patient was sensitised to the rest of the propionic acid group, but due to the small area affected skin, we could not test these additional drugs. Therefore all propionic acid group drugs were forbidden. The patient tolerated acetylsalicylic acid, and then we recommended the use of the rest of non-steroidal antiinflammatory drugs. Díaz-Jara et al. described two children, one of them with a fixed drug eruption after the ingestion of ibuprofen. Patch test was positive with ibuprofen on the residual lesion. Kanwar et al. analysed 98 cases of fixed drug eruption and in only six of these ibuprofen was the responsible drug. The diagnosis was performed by provocation tests. Kuligowski et al. described a patient with a multiple fixed drug eruption with mucosa affectation due to ibuprofen. Patch test was positive on affected skin. In summary, we report a case of fixed drug eruption due to ibuprofen that was confirmed by positive patch test and skin biopsy. The patient tolerated acetylsalicylic acid, therefore all propionic acid group drugs were forbidden.